منابع مشابه
New Trypanosoma evansi Type B Isolates from Ethiopian Dromedary Camels.
BACKGROUND Trypanosoma (T.) evansi is a dyskinetoplastic variant of T. brucei that has gained the ability to be transmitted by all sorts of biting flies. T. evansi can be divided into type A, which is the most abundant and found in Africa, Asia and Latin America and type B, which has so far been isolated only from Kenyan dromedary camels. This study aimed at the isolation and the genetic and ph...
متن کاملTrypanosoma Evansi Infections
Definition of the disease: Trypanosoma evansi causes a disease known as Trypanosomosis1 (‘surra’). It affects a number of species of domesticated animals in Asia, Africa and Central and South America. The principal host species affected varies geographically, but buffalo, cattle, camels and horses are particularly affected, although other animals, including wildlife, are also susceptible. It is...
متن کاملTrypanosoma Evansi Infections
Definition of the disease: Trypanosoma evansi causes a disease known as Trypanosomosis1 5 (‘surra’). It affects a number of domesticated animals species in Asia, Africa and Central and South 6 America. The principal host species affected varies geographically, but buffalo, cattle, camels and 7 horses are particularly affected, although other animals, including wildlife, are also susceptible. It...
متن کاملExpression, purification and preliminary crystallographic analysis of oligopeptidase B from Trypanosoma brucei
African sleeping sickness, also called trypanosomiasis, is a significant cause of morbidity and mortality in sub-Saharan Africa. Peptidases from Trypanosoma brucei, the causative agent, include the serine peptidase oligopeptidase B, a documented virulence factor and therapeutic target. Determination of the three-dimensional structure of oligopeptidase B is desirable to facilitate the developmen...
متن کاملCrystal Structures of Trypanosoma brucei Oligopeptidase B Broaden the Paradigm of Catalytic Regulation in Prolyl Oligopeptidase Family Enzymes
Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target. Here we present ligand-free open state and inhibitor-bound closed state crystal structures of oligopeptidase B from Trypanosoma brucei, the causative agent of African sleeping sickness...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m410066200